O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT.
1. Goodtzova, K., et al., 1994. Activation of human O6-alkylguanine-DNA alkyltransferase by DNA. Biochemistry. 33(28): 8385-90. PMID: 8031773 2. Elder, R H., et al., 1994. Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine. The Biochemical journal. 298 ( Pt 1)(): 231-5. PMID: 8129725 3. Dolan, M E., et al., 1997. O6-benzylguanine and its role in chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 3(6): 837-47. PMID: 9815757 4. Kreklau, E L., et al., 1999. Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. 291(3): 1269-75. PMID: 10565851
Soluble in methanol (20 mg/ml), and aqueous alkali (Heated).
How should this chemical be stored, once it is in a solution with methanol?
Asked by: two2igm05
Thank you for your question.
The solution should be tightly sealed and stored at -20 degrees Celsius; it is recommended to be used as soon as possible.
Please contact Technical Service if you have further questions concerning this product.
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Kreklau et alKreklau et al. (PubMed ID 10565851) found that O6-Benzylguanine blocked methylguanine DNA methyltransferase (MGMT) activity in tumor cells and xenograft tumors. -SCBT Publication Review
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