O-DeacetylravidomycinA more active and stable analogue of the ravidomycin complex

O-Deacetylravidomycin (CAS 88580-27-2)

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Application: A more active and stable analogue of the ravidomycin complex
CAS Number: 88580-27-2
Purity: >95%
Molecular Weight: 521.57
Molecular Formula: C29H31NO8
* Refer to Certificate of Analysis for lot specific data (including water content).
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O-deacetylravidomycin is the more active and stable analogue of the ravidomycin complex produced by Streptomyces ravidus. The metabolite shows potent, light dependent antitumour activity. O-Deacetylravidomycin is an inhibitor of Topo II. Microbial Screening Technologies in-house bioassays detected weak antibacterial and antifungal activity.


References

1. New ravidomycin analogues, FE35A and FE35B, apoptosis inducers produced by Streptomyces rochei. Yamashita N. et al. J. Antibiot. 1998, 51, 1105. 2. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II. Lorico A. et al. Eur. J. Cancer 1993, 29A, 1985. 3. Light-dependent activity of the antitumor antibiotics ravidomycin and desacetylravidomycin. Greenstein M. et al. Antimicrob. Agents Chemother. 1986, 29, 861. 4. Chemical modification of ravidomycin and evaluation of biological activities of its derivatives. Rakhit S. et al. Antimicrob. Agents Chemother. 1986, 29, 861.

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in DMSO, DMF, ethanol (Moderately), and methanol (Moderately).
Storage :
Store at 4° C
Boiling Point :
791.96° C at 760 mmHg (Predicted)
Density :
1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23815308
SMILES :
C[C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C2=C3C(=C(C=C2)O)C(=CC4=C3OC(=O)C5=CC(=CC(=C54)OC)C=C)OC)O)N(C)C)O

Download SDS (MSDS)

Certificate of Analysis

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