NVP-BHG712CAS: 940310-85-0
MF: C26H20F3N7O
MW: 503.48
An RTK auto-phosphorylation inhibitor for transfected A375 cells..

NVP-BHG712 (CAS 940310-85-0)

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Synonym: 4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide
Application: An RTK auto-phosphorylation inhibitor for transfected A375 cells.
CAS Number: 940310-85-0
Purity: ≥99%
Molecular Weight: 503.48
Molecular Formula: C26H20F3N7O
* Refer to Certificate of Analysis for lot specific data (including water content).
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NVP-BHG712 treatment leads to the inhibition of RTK auto-phosphorylation in stable transfected A375 melanoma cells with EC50 of 25 nM and 4.2 μM for EphB4 and VEGFR2, respectively. NVP-BHG712 is a specific inhibitor of c-Raf, c-Src, and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16747388
SMILES :
CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=NC(=NC4=C3C=NN4C)C5=CN=CC=C5

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Certificate of Analysis

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