NU 9056A selective KAT5 histone acetyltransferase inhibitor

NU 9056 (CAS 1450644-28-6)

NU 9056 | CAS 1450644-28-6 is rated 5.0 out of 5 by 1.
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Synonym: 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
Application: A selective KAT5 histone acetyltransferase inhibitor
CAS Number: 1450644-28-6
Molecular Weight: 232.37
Molecular Formula: C6H4N2S4
* Refer to Certificate of Analysis for lot specific data (including water content).
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NU 9056 is a selective cPLA2 (KAT5) histone acetyltransferase inhibitor. It has been shown to inhibit acetylation of proteins in prostate cancer cell lines. It block DNA damage response. It decreases proliferation of LNCap cells, and induces apoptosis by caspase activation.

Formulation :
10 mg/ml in DMSO
Physical State :
Liquid
Solubility :
Soluble in DMSO.(supplied pre-dissolved in DMSO, 10 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
KAT5/TIP60: IC50 ≤ 2 µM; PCAF: IC50 ≤ 36 µM; p300: IC50 ≤ 60 µM; GCN5: IC50 > 100 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
72201043
SMILES :
C1=NSC(=C1)SSC2=CC=NS2

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NU 9056  Product Citations

See how others have used NU 9056. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27165113  2016. Neuromolecular Med.

Citations 1 to 1 of 1 total

What is the half life of NU9056?

Asked by: mlschuma
Thank you for your question. This information is not currently available, but please contact our Technical Service Department if you have additional questions.
Answered by: Technical Support
Date published: 2018-12-11
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Rated 5 out of 5 by from Ceffey et al Ceffey et al. (PubMed ID 23056207) found that the Tip60 inhibitor, NU 9056, blocked cell proliferation in prostate cancer cell lines and induced apoptosis via activation of caspase 3 and caspase 9. -SCBT Publication Review
Date published: 2015-01-04
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