nTZDpaA non-thiazolidinedione PPARγ partial agonist

nTZDpa (CAS 118414-59-8)

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Application: A non-thiazolidinedione PPARγ partial agonist
CAS Number: 118414-59-8
Purity: ≥98%
Molecular Weight: 428.33
Molecular Formula: C22H15Cl2NO2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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nTZDpa is a potent, selective non-thiazolidinedione PPARγ partial agonist; with ~25% maximum efficacy. nTZDpa antagonizes full agonist activity by ~60%. Displays no activity at PPARα or PPARδ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPARγ agonists. nTZDpa modulates metabolism and insulin sensitivity.


References

1. Berger, Joel P., et al., 2003. Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. Molecular endocrinology (Baltimore, Md.). 17(4): 662-76. PMID: 12554792

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
Melting Point :
185-188° C
Boiling Point :
628.95° C at 760 mmHg (Predicted)
Density :
1.38 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
PPARγ: IC50 = 26 nM (human); PPARγ: EC5050 = 57 nM; PPARα: IC50 >15 µM (human)
pK Values :
pKa: 3.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9954280
MDL Number :
MFCD06798322
SMILES :
Clc1ccc(cc1)Cn1c2ccc(Cl)cc2c(Sc2ccccc2)c1C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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