γ Enolase Antibody (AT17D10) is a mouse monoclonal IgG2b antibody that detects γ Enolase in human samples through applications such as western blotting (WB), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). γ Enolase, one of the three isoenzymes of enolase, is primarily expressed in nervous tissue and plays a crucial role in the glycolytic pathway by catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate, a key step in energy production. This enzymatic function is particularly important in neurons, where energy demands are high, and disruptions in glycolytic activity can lead to neurodegenerative conditions. Anti-γ Enolase antibody (AT17D10) targets proteins in the cytoplasm of neurons, highlighting a role in metabolism and serving as a potential biomarker for neuronal injury, making γ Enolase monoclonal antibody (AT17D10) an invaluable tool for researchers studying neurological diseases and cellular metabolism.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
γ Enolase Antibody (AT17D10) References:
- Molecular evolution of enolase. | Piast, M., et al. 2005. Acta Biochim Pol. 52: 507-13. PMID: 15912209
- Gamma-enolase: a well-known tumour marker, with a less-known role in cancer. | Vizin, T. and Kos, J. 2015. Radiol Oncol. 49: 217-26. PMID: 26401126
- Gamma-enolase predicts lung damage in severe acute pancreatitis-induced acute lung injury. | Owusu, L., et al. 2018. J Mol Histol. 49: 347-356. PMID: 29728894
- Enolase isoenzymes as tumour markers. | Gerbitz, KD., et al. 1986. J Clin Chem Clin Biochem. 24: 1009-16. PMID: 3029273
- γ-Enolase enhances Trk endosomal trafficking and promotes neurite outgrowth in differentiated SH-SY5Y cells. | Pišlar, A. and Kos, J. 2021. Cell Commun Signal. 19: 118. PMID: 34895236
- γ-enolase (ENO2) is methylated at the Nτ position of His-190 among enolase isozymes. | Kasai, F., et al. 2023. J Biochem. 174: 279-289. PMID: 37279646
- Multifunctional roles of γ-enolase in the central nervous system: more than a neuronal marker. | Horvat, S., et al. 2024. Cell Biosci. 14: 61. PMID: 38735971
- Olfactory neuroblastoma: A rare sinonasal malignancy. | Uppal, AA., et al. 2024. J Pak Med Assoc. 74: 1370-1373. PMID: 39028075
- [Gamma-enolase (gamma-eno)]. | Koyama, R. 1995. Nihon Rinsho. 53: 1277-81. PMID: 7602791
- Enolase activity and isoenzyme distribution in human brain regions and tumors. | Joseph, J., et al. 1996. J Neurochem. 66: 2484-90. PMID: 8632173