NSC 95397A quinone-based Cdc25 inhibitor, caspase-3 activator, ERK activator, and MKP inhibitor

NSC 95397 (CAS 93718-83-3)

NSC 95397 | CAS 93718-83-3 is rated 5.0 out of 5 by 1.
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Synonym: 2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone
Application: A quinone-based Cdc25 inhibitor, caspase-3 activator, ERK activator, and MKP inhibitor
CAS Number: 93718-83-3
Purity: >97%
Molecular Weight: 310.38
Molecular Formula: C14H14O4S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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NSC 95397 is a selective and effective dual-specificity, quinone-based phosphatase inhibitor. The compound has been reported to inhibit Cdc25A, B and C, and is more selective than VH1-related dual-specificity phosphatase or protein tyrosine phosphatase 1b. Cdc25A is a phosphatase vital for the progression of the cell cycle and NSC 95397 has been noted to inhibit the G2/M phase transition and cell growth. NSC 95397 has demonstrated the ability to activate ERK-1 and ERK-2, induce tyrosine phosphorylation of EGFR, activate caspase-3, and inhibit MKP-1 and MKP-3.


References

1. Lazo, J.S., et al. 2002. Mol. Pharmacol. 61: 720-728. PMID: 11901209
2. Han, Y., et al. 2004. J. Pharmacol. Exp. Ther. 309: 64-70. PMID: 14718602
3. Melchheier, I., et al. 2005. Biochem. Biophys. Res. Commun. 327: 1016-1023. PMID: 15652497
4. Vogt, A., et al. 2008. Mol. Cancer Ther. 7: 330-340. PMID: 18245669
5. Larsson, D.E., et al. 2010. Anticancer Res. 30: 149-156. PMID: 20150630

Physical State :
Solid
Solubility :
Soluble in DMSO (16 mg/ml), ethanol (5 mM), and DMSO (50 mM).
Storage :
Store at -20° C
Boiling Point :
499.16° C at 760 mmHg
Density :
1.46 g/cm3
Refractive Index :
n20D 1.68
IC50 :
Large T antigen: EC5050 = 28240 nM (Simian virus 40); Dual specificity phosphatase Cdc25C: IC50 = 56.9 nM (human); CHO (Ovarian cells): IC50 = 479.38 nM (Cricetulus griseus); Dual specificity phosphatase Cdc25B: IC50 = 100 nM (human); Toll-like receptor 9: IC50 = 1869 nM (human); recombinant human Cdc25B: IC50 = <500 nM
Ki Data :
Cdc25A: Ki= 32 nM; Cdc25B: Ki= 96 nM; Cdc25C: Ki= 40 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
262093
MDL Number :
MFCD04040032
SMILES :
C1=CC=C2C(=C1)C(=O)C(=C(C2=O)SCCO)SCCO

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NSC 95397  Product Citations

See how others have used NSC 95397. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 29041978  Peng, WX. et al. 2017. Mol. Cancer. 16: 161.

PMID: # 26859151  Boulding, T. et al. 2016. PloS one. 11: e0148065.

PMID: # 19269962  Panchal, RG. et al. 2009. J. Biol. Chem. 284: 12874-12885.

PMID: # 18245669  Vogt, A. et al. 2008. Mol. Cancer Ther. 7: 330-340.

PMID: # 11901209  Lazo, JS. et al. 2002. Mol. Pharmacol. 61: 720-728.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Cdc25 inhibitor Cdc25 inhibitor, NSC 95397, prevents lambda protein phosphatase from de-phosphorylating p-NFkB p50. This is demonstrated by IF when an increase in nuclear localization and signal when comparing lambda protein phosphatase treated NIH/3T3 cells with those that have been treated with both lambda protein phosphatase and the inhibitor in question. This is also demonstrated by treatment of K-562 cells with both the above mentioned phosphatase and NSC 95397, followed by WB analysis. The presence of this compound has prevented lambda protein phosphatase from de-phosphorylating p-Cofilin 1. -SCBT QC
Date published: 2015-02-14
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