NSC 87877A potent inhibitor of shp2 and shp1 protein tyrosine phosphatases

NSC 87877 (CAS 56990-57-9)

NSC 87877 | CAS 56990-57-9 is rated 5.0 out of 5 by 1.
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Synonym: 8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic Acid
Application: A potent inhibitor of shp2 and shp1 protein tyrosine phosphatases
CAS Number: 56990-57-9
Purity: >98%
Molecular Weight: 459.45
Molecular Formula: C19H13N3O7S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1). IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR, respectively. NSC 87877 has also been shown to inhibit EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability and/or proliferation.


References

1. Chen, L.,et al. 2006. Mol. Pharmacol. 70: 562-570. PMID: 16717135
2. Zhao, X.T., et al. 2007. Dev Neurobiol. 67: 1789-1801. PMID: 17659592
3. Redondo, P.C., et al. 2007. J. Thromb. Haemost. 5: 2476-2483. PMID: 17892531

Physical State :
Solid
Solubility :
Soluble in water (50 mM), and DMSO (20 mM).
Storage :
Desiccate at 4° C
Melting Point :
329.89° C (Predicted)
Density :
~1.70 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
SH-PTP2: IC50 = 0.318 µM; SH-PTP1: IC50 = 0.355 µM; PTP1B: IC50 = 1.691 µM; HePTP: IC50 = 7.745 µM; DEP-1: IC50 = 65.617 µM
pK Values :
pKa: -0.89 (Predicted), pKb: 7.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5459322
MDL Number :
MFCD09971104
SMILES :
C1=CC2=C(C(=O)/C(=N/NC3=CC4=C(C=C3)C=C(C=C4)S(=O)(=O)O)/C=C2S(=O)(=O)O)N=C1

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Certificate of Analysis

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NSC 87877  Product Citations

See how others have used NSC 87877. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 30764849  Pérez-Fernández, A. et al. 2019. J. Exp. Clin. Cancer Res. 38: 80.

PMID: # 29708510  Ubil, E. et al. 2018. J. Clin. Invest. 128: 2356-2369.

PMID: # 30108215  Zehender, A. et al. 2018. Nat Commun. 9: 3259.

PMID: # 28183800  Yang, GL. et al. 2017. FASEB J. 31: 2001-2012.

PMID: # 28919207  Yamashita, N. et al. 2017. Dev. Cell. 42: 626-639.e5.

PMID: # 26794644  Augello, G. et al. 2016. Cell Cycle. 15: 573-83.

PMID: # 26342897  Choi, YR. et al. 2015. Neurobiology of disease. 83: 90-9.

PMID: # 24248601  Cheng, SY. et al. 2014. Mol. Cell. Biol. 34: 348-61.

PMID: # 23418871  Tourdot, BE. et al. 2013. Biochemistry. 52: 2597-608.

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from Shi Shi, Y. et al. (PubMed 26247726) found that NSC 87877, an Inhibitor of shp1 and shp2 PTP, inhibited dual specificity protein phosphatase 26 (DUSP26), a protein that is overexpressed in high-risk neuroblastoma and inhibits p53 function. Inhibition of DUSP26 resulted in increased p53 phosphorylation and activation leading to p53-mediated apoptosis. -SCBT Publication Review
Date published: 2015-07-11
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