NSC 632839 hydrochlorideAn inhibitor of ubiquitin isopeptidase activity

NSC 632839 hydrochloride (CAS 157654-67-6)

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Synonym: 3,5-Bis[(4-methylphenyl)methylene]- 4-piperidone hydrochloride
Application: An inhibitor of ubiquitin isopeptidase activity
CAS Number: 157654-67-6
Purity: ≥99%
Molecular Weight: 339.86
Molecular Formula: C21H21NO.HCl
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NSC 632839 hydrochloride is an inhibitor of USP (ubiquitin isopeptidase) activity that displays no effect on the proteolytic activity of the proteasome. Induces apoptosis via a Bcl-2-dependent and apoptosome-independent pathway of caspase activation.


References

1. Aleo, E., et al. 2006. Cancer Res. 66: 9235-9244. PMID: 16982768

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mM).
Storage :
Store at 4° C
Boiling Point :
522.7° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
CEM: IC50 = 1.69 µM (human); L1210: IC50 = 8.47 µM (mouse); E1A cells: IC50 = 15.65 µM; E1A/C9CN cells: IC50 = 16.23 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
365286
MDL Number :
MFCD09753281
SMILES :
CC1=CC=C(C=C1)C=C2CNCC(=CC3=CC=C(C=C3)C)C2=O.Cl

Download SDS (MSDS)

Certificate of Analysis

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