NSC 625987 CAS: 141992-47-4
MF: C15H13NO2S
NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor.

NSC 625987 (CAS 141992-47-4)

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Alternate Names: 1,4-Dimethoxy-9(10H)-acridinethione
Application: NSC 625987 is a cyclin-dependent kinase (cdk) 4 inhibitor
CAS Number: 141992-47-4
Purity: ≥95%
Molecular Weight: 271.33
Molecular Formula: C15H13NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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NSC 625987 is a Cdk4 (cyclin-dependent kinase (cdk) 4) inhibitor (IC50 = 0.2 μM at Cdk4 (cdk4)/cyclin D1). The compound displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).


References

Kubo et al (1999) The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin.Cancer Res. 5 4279. McInnes et al (2004) Structural determinants of CDK4 inhibition and design of selective ATP competit

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), and ethanol (2.5 mg/ml).
Storage :
Store at 4° C
Melting Point :
182.57° C (Predicted)
Boiling Point :
460.38° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Cdk4/cyclin D1: IC50 = 0.2 µM; Cdk1/cyclin A: IC50 > 100 µM; Cdk2/cyclin A: IC50 > 100 µM; Cdk2/cyclin E: IC50 > 100 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD08276925
SMILES :
COC1=C2C(=C(C=C1)OC)NC3=CC=CC=C3C2=S

Download SDS (MSDS)

Certificate of Analysis

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