NSC 625987 is a Cdk4 (cyclin-dependent kinase (cdk) 4) inhibitor (IC50 = 0.2 μM at Cdk4 (cdk4)/cyclin D1). The compound displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
Kubo et al (1999) The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin.Cancer Res. 5 4279. McInnes et al (2004) Structural determinants of CDK4 inhibition and design of selective ATP competit