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NSC 625987 is a Cdk4 (cyclin-dependent kinase (cdk) 4) inhibitor (IC50 = 0.2 μM at Cdk4 (cdk4)/cyclin D1). The compound displays > 500-fold selectivity over cdk2 (IC50 > 100 μM for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).
1. Kubo, A., et al. 1999. Clin. Cancer Res. 5: 4279-4286.
2. McInnes, C., et al. 2004. Chem. Biol. 11: 525-534.
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