NSC 3852An inhibitor of HDAC (histone deacetylase)

NSC 3852 (CAS 3565-26-2)

NSC 3852 | CAS 3565-26-2 is rated 5.0 out of 5 by 1.
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Application: An inhibitor of HDAC (histone deacetylase)
CAS Number: 3565-26-2
Molecular Weight: 174.16
Molecular Formula: C9H6N2O2
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* Refer to Certificate of Analysis for lot specific data (including water content).
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NSC 3852 is an HDAC (histone deacetylase) inhibitor. In MCF-7 human breast cancer cells, NSC 3852 causes cell differentiation in vitro and posses antiproliferative activity in MCF-7 human breast cancer cells .


References

1. Martirosyan, A.R., et al. 2004. Biochem. Pharmacol. 68: 1729-1738. PMID: 15450938
2. Martirosyan, A., et al. 2006. J. Pharmacol. Exp. Ther. 317: 546-552. PMID: 16497787

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (10 mM).
Storage :
Store at room temperature
Melting Point :
110.83° C (Predicted)
Boiling Point :
403.35° C at 760 mmHg (Predicted)
Density :
1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
XBP-1: IC50 = 5.08 µM (human); BJ: EC5050 = 8.73 µM (human); DNA damage-inducible transcript 3 protein: IC50 > 8.83 µM (mouse); Exodeoxyribonuclease V: IC50 >118.59 µM (Escherichia coli (strain K12))
pK Values :
pKa: 2.73 (Predicted), pKb: 7.1 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
VC8237000
PubChem CID :
19103
MDL Number :
MFCD00041862
EC Number :
222-650-6
Beilstein Registry :
0135353
SMILES :
C1=CC2=C(C=CC(=C2N=C1)O)N=O

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Certificate of Analysis

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Rated 5 out of 5 by from Martirosyan et al Martirosyan et al. (PubMed ID 16497787) found that NSC 3852 induced apoptotic and cell differentiation via ROS production in MCF-7 cells. -SCBT Publication Review
Date published: 2015-03-04
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