NSC 146109 hydrochlorideAn antitumor activator of p53-dependent transcription

NSC 146109 hydrochloride (CAS 59474-01-0)

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Synonym: (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
Application: An antitumor activator of p53-dependent transcription
CAS Number: 59474-01-0
Molecular Weight: 316.85
Molecular Formula: C17H16N2S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases the level of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. NSC 146109 hydrochloride displays some selectivity for tumor cells vs. normal cells in an MTT cell viability assay.


References

1. Dolma, S., et al. 2003. Cancer Cell. 3: 285-396.
2. Berkson, R.G., et al. 2005. Int. J. Cancer. 115: 701-710.

Physical State :
Solid
Solubility :
Soluble in ethanol (10 mM), and DMSO (100 mM).
Storage :
Store at room temperature
Refractive Index :
n20D 1.67 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16759161
MDL Number :
MFCD09878281
SMILES :
CC1=C2C=CC=CC2=C(C3=CC=CC=C13)CSC(=N)N.Cl

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Certificate of Analysis

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