NSC 109555 ditosylate is an ATP-competitive reversible Chk2 (checkpoint kinase 2) inhibitor that displays no effect on a range of other kinases, including Chk1. NSC 109555 ditosylate inhibits H1 phosphorylation as well as attenuates mitochondrial ATP synthesis.
Byczkowski et al (1981) Actions of bis(guanylhydrazones) on isolated rat liver mitochondria. Biochem.Pharmacol. 30 2851. Byczkowski et al (1982) Potentiation of the antimitochondrial and antiproliferative effects of bis(guanylhydrazones) by phenethylbiguanide. Cancer Res. 42 3592. Jobson et al (2007) Identification of a bis-guanylhydrazone [4,4'-diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a novel chemotype for inhibition of Chk2 kinase. Mol.Pharmacol. 72 876.
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