NS 3763 is a selective non-competitive kainate receptor antagonist; displays selectivity for GLUK5 subunit-containing receptors (IC50 values are 1.6 and > 30 mM for homomeric GLUK5 and GLUK6 receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50 >> 30 mM).
1. Christensen, J.K., et al. 2004. J. Pharmacol. Exp. Ther. 309: 1003-1010.
Soluble to 25 mM in DMSO
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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