NS 1643 is a HERG(hERG K+ channel) activator, such as KCNH6. Displays different molecular mechanisms of action at hERG1 and hERG2 channels. Exhibits antiarrhythmic activity in vitro.
Hansen et al (2006) Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol.Pharmacol. 69 266. Casis et al (2006) Mechanism of action of a novel human ether-a-go-ao related gene channel activator. Mol.Pharmacol. 69 658. Elmedyb et al (2007) Activation of ERG2 potassium channel by the diphenylurea NS1643. Neuropharmacology 53 283.
Soluble in ethanol (100 mM), and DMSO (≥20 mg/ml).
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Rated 5 out of
Lansu et alLansu et al. (PubMed ID 23744352) found that the hERG1 channel activator, NS1643, inhibited breast cancer cell proliferation irreversibly by inducing cell cycle arrest in G0/G1 phase. -SCBT Publication Review
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