NPC 15199An N-protected leucine analog

NPC 15199 (CAS 35661-60-0)

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Synonym: Fmoc-Leu
Application: An N-protected leucine analog
CAS Number: 35661-60-0
Molecular Weight: 353.4
Molecular Formula: C21H23NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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NPC 15199 is an N-(9-fluorenylmethoxycarbonyl)-protected leucine compound that demonstrates antiinflammatory effects. NPC 15199 and other N-(9-fluorenylmethoxycarbonyl)-protected amino acids are demonstrated to block recruitment of neutrophils into inflammatory lesions and to inhibit T-cell activation in vitro, and are classified as leumedins. NPC 15199 is described to act as a chemically distinct ligand and modulator of PPARγ (peroxisome proliferator-activated receptor γ). NPC 15199 is demonstrated to increase intracellular Ca2+ and to mobilize Ca2+ stores in human bladder female transitional cancer (BFTC) cells.


1. Burch, R.M., et al. 1991. Proc. Natl. Acad. Sci. U.S.A. 88: 355-359. PMID: 1824872
2. Miller, M.J., et al. 1993. J. Pharmacol. Exp. Ther. 266: 468-472. PMID: 8392562
3. Jan, C.R., et al. 2000. Chin J Physiol. 43: 29-33. PMID: 10857466
4. Rocchi, S., et al. 2001. Mol. Cell. 8: 737-747. PMID: 11684010

Physical State :
Solubility :
Soluble in methanol, DMSO (~30 mg/ml), DMF (~30 mg/ml), ethanol (~30 mg/ml), and solution of ethanol:PBS (pH 7.2) (~0.5 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
152-156° C (lit.)
Refractive Index :
n20D ~1.58 (Predicted)
Optical Activity :
α20/D -25°±2°, c = 1 in DMF; α20/D -7°±1°, c = 1 in ethyl acetate (Predicted)
Ki Data :
PPARγ: Ki= 15 µM; PPARα: Ki= >50 µM; PPARδ: Ki= >50 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :
EC Number :
Beilstein Registry :

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Certificate of Analysis

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