NPC 15199 is an N-(9-fluorenylmethoxycarbonyl)-protected leucine compound that demonstrates antiinflammatory effects. NPC 15199 and other N-(9-fluorenylmethoxycarbonyl)-protected amino acids are demonstrated to block recruitment of neutrophils into inflammatory lesions and to inhibit T-cell activation in vitro, and are classified as leumedins. NPC 15199 is described to act as a chemically distinct ligand and modulator of PPARγ (peroxisome proliferator-activated receptor γ). NPC 15199 is demonstrated to increase intracellular Ca2+ and to mobilize Ca2+ stores in human bladder female transitional cancer (BFTC) cells.
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