Noscapine hydrochlorideA bradykinin B and tubulin inhibitor

Noscapine hydrochloride (CAS 912-60-7)

Noscapine hydrochloride | CAS 912-60-7 is rated 5.0 out of 5 by 1.
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Synonym: Narcotine hydrochloride
Application: A bradykinin B and tubulin inhibitor
CAS Number: 912-60-7
Purity: ≥98%
Molecular Weight: 449.88
Molecular Formula: C22H23NO7•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Additionally Noscapine binds to tubulin, arrests cells in mitosis and induces apoptosis. Blocks proliferation of human leukemia and multiple myeloma cells. Furthermore, Noscapine modulates IKK activation, suppressing the NF-κB signaling pathway. Exhibits anti-inflammatory activity. Noscapine hydrochloride is an inhibitor of Tubulin.


References

1. Mourey, R.J., et al. 1992. Mol. Pharmacol. 42: 619-626.
2. Ye, K., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 1601-1606.
3. Mahmoudian, M. and Mojaverian, M. 2001. Acta Physiol. Hung. 88: 231-237.
4. Landen, J.W., et al. 2002. Cancer Res. 62: 4109-4114.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water, and 1eq. HCl (50 mM).
Storage :
Desiccate at room temperature
Melting Point :
221-223° C
Refractive Index :
n20D ~1.60 (Predicted)
IC50 :
CYP2C19: IC50 = 400.3 nM (human); HepG2: IC50 >1000 nM (human); A549: EC5050 = 25 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16667685
Merck Index :
14: 6718
MDL Number :
MFCD00082546
EC Number :
213-014-9
SMILES :
CN1CCC2=CC3=C(C(=C2[C@@H]1[C@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OC)OCO3.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Salminen et al Salminen et al. (PubMed ID 26400396) found that Noscapine hydrochloride inhibited the cytochrome P450 2C19 (CYP2C19) enzyme in a time-dependent manner in vitro. -SCBT Publication Review
Date published: 2015-02-16
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