Norneo SildenafilAn analog of Sildenafil and potential PDE5 inhibitor

Norneo Sildenafil (CAS 371959-09-0)

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Synonym: 5-[2-Ethoxy-5-(1-piperidinylsulfonyl)phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one
Application: An analog of Sildenafil and potential PDE5 inhibitor
CAS Number: 371959-09-0
Molecular Weight: 459.56
Molecular Formula: C22H29N5O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Norneo Sildenafil is an analog of Sildenafil (sc-338584). Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.

Physical State :
Solid
Storage :
Store at 4° C
Melting Point :
190-193° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1896867
SMILES :
CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCCCC4)OCC)C

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Certificate of Analysis

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