Molecular structure of Norethindrone, CAS Number: 68-22-4
Norethindrone (CAS 68-22-4)
Alternate Names:
Norethisterone; Menzol; Micronovum
Application:
Norethindrone is a synthetic progestin
CAS Number:
68-22-4
Purity:
≥98%
Molecular Weight:
298.42
Molecular Formula:
C20H26O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Norethindrone is a synthetic progestin which in low doses is progestational and in high doses is antiestrogenic. It also causes a time-dependent loss of cytochrome P-450 when incubated in vitro with rat liver microsomal fractions in NADPH-generating systems. Norethindrone binds to progesterone receptors, which are found in the uterus, ovary, and other tissues. It then activates the progesterone receptor, which in turn activates a series of intracellular signaling pathways. These pathways ultimately lead to the inhibition of ovulation, the inhibition of cell proliferation, and the induction of cell differentiation.
Norethindrone (CAS 68-22-4) References
- Controlled delivery system for norethindrone based on biodegradable poly-alpha,beta-(hydroxyalkyl)-DL-aspartamide. | Tang, G., et al. 2002. Drug Deliv. 9: 215-22. PMID: 12511199
- Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes. | Madauss, KP., et al. 2004. J Med Chem. 47: 3381-7. PMID: 15189034
- Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. | Korhonen, T., et al. 2008. J Steroid Biochem Mol Biol. 110: 56-66. PMID: 18356043
- [Interaction of norethindrone on estrogen and progesterone receptors in the rabbit uterine cytosol (author's transl)]. | Tamaya, T., et al. 1975. Nihon Naibunpi Gakkai Zasshi. 51: 1033-42. PMID: 183990
- Simple and rapid determination of norethindrone in human plasma by supported liquid extraction and ultra performance liquid chromatography with tandem mass spectrometry. | Gong, Z., et al. 2012. Talanta. 91: 77-82. PMID: 22365683
- Antiproliferative and apoptotic effects of norethisterone on endometriotic stromal cells in vitro. | Minami, T., et al. 2013. Eur J Obstet Gynecol Reprod Biol. 166: 76-80. PMID: 22964137
- Metabolism of norethisterone in the greyhound. | Biddle, ST., et al. 2013. Rapid Commun Mass Spectrom. 27: 2229-38. PMID: 24019188
- Norethisterone interference in testosterone assays. | Jeffery, J., et al. 2014. Ann Clin Biochem. 51: 284-8. PMID: 24265092
- The effect of protease inhibitors on the cervical mucus of HIV-positive women taking norethindrone contraception. | Atrio, J., et al. 2015. Eur J Contracept Reprod Health Care. 20: 149-53. PMID: 25285572
- Investigation on the Interaction of Norgestrel with Human Serum Albumin Using Spectroscopy and Molecular-Docking Method. | Ma, X., et al. 2016. J Biochem Mol Toxicol. 30: 287-94. PMID: 26778492
- Probing Steroidal Substrate Specificity of Cytochrome P450 BM3 Variants. | Liu, X., et al. 2016. Molecules. 21: PMID: 27294908
- The Use of Norethisterone for the Treatment of Severe Uterine Bleeding in Adolescents: An Audit of Our Experience. | Papapanagiotou, IK., et al. 2019. J Pediatr Adolesc Gynecol. 32: 596-599. PMID: 31520717
- Norethindrone alters growth, sex differentiation and gene expression in marine medaka (Oryzias melastigma). | Dong, Z., et al. 2022. Environ Toxicol. 37: 1211-1221. PMID: 35098644
- Differential off-target glucocorticoid activity of progestins used in endocrine therapy. | Komane, M., et al. 2022. Steroids. 182: 108998. PMID: 35271867
- Decreased liver cytochrome P-450 in rats caused by norethindrone or ethynyloestradiol. | White, IN. and Muller-Eberhard, U. 1977. Biochem J. 166: 57-64. PMID: 901418
Inhibitor of:
AKR1C13, Oviductin, and Progesterone.Activator of:
mPR, mPRγ, and PR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Norethindrone, 250 mg | sc-204822 | 250 mg | $38.00 | |||
Norethindrone, 500 mg | sc-204822B | 500 mg | $69.00 | |||
Norethindrone, 1 g | sc-204822A | 1 g | $125.00 | |||
Norethindrone, 5 g | sc-204822C | 5 g | $497.00 |