Nolatrexed DihydrochlorideAn inhibitor of thymidylate synthase

Nolatrexed Dihydrochloride (CAS 152946-68-4)

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Synonym: 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone Hydrochloride; AG 337; Thymitaq
Application: An inhibitor of thymidylate synthase
CAS Number: 152946-68-4
Purity: ≥98%
Molecular Weight: 357.26
Molecular Formula: C14H14Cl2N4OS
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nolatrexed Dihydrochloride is an antineoplastic, antifolate TS (thymidylate synthase) inhibitor.


References

1. Webber, S E., et al., 1993. Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones. Journal of medicinal chemistry. 36(6): 733-46. PMID: 8459400
2. Webber, S., et al., 1996. AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer chemotherapy and pharmacology. 37(6): 509-17. PMID: 8612303
3. Dash, A K., et al., 1996. Solid-state characterization of AG337 (Thymitaq), a novel antitumor drug. Journal of pharmaceutical sciences. 85(10): 1123-7. PMID: 8897283
4. Rafi, I., et al., 1995. Clinical pharmacokinetic and pharmacodynamic studies with the nonclassical antifolate thymidylate synthase inhibitor 3, 4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by 24-hour continuous intravenous infusion. Clinical cancer research : an official journal of the American Association for Cancer Research. 1(11): 1275-84. PMID: 9815922
5. Stuart, K., et al., 1999. A Phase II trial of nolatrexed dihydrochloride in patients with advanced hepatocellular carcinoma. Cancer. 86(3): 410-4. PMID: 10430248

Physical State :
Solid
Solubility :
Soluble in Methanol (>3 mg/ml)
Storage :
Store at -20° C
Melting Point :
>270° C (dec.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
108188
SMILES :
CC1=C(C2=C(C=C1)NC(=NC2=O)N)SC3=CC=NC=C3.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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