NNC 55-0396 is a nonhydrolyzable analog of Mibefradil dihydrochloride (sc-204083) which functions as a selective T-type calcium channel protein inhibitor. Studies indicate that NNC 55-0396 displays similar potency on T-type Ca2+ currents in HEK 293/α1G as Mibefradil. NNC 55-0396 can be an essential tool in preventing human ovarian cancer cell proliferation as a result of its ability to inhibit the function of T-type Ca2+ channels. It is believed that NNC 55-0396 may function by dissolving in or passing through the plasma membrane of cells.
1. Huang, L., et al. 2004. J. Pharmacol. Exp.Ther. 309: 193-199.<
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Huang et alHuang et al. (PubMed ID 25989794) found that the T-type Ca(2+) channel inhibitors NNC-55-0396 inhibited leukemia cell proliferation and induced apoptosis. -SCBT Publication Review
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