NKH 477A potent activator of adenylyl cyclase

NKH 477 (CAS 138605-00-2)

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Synonym: 6-[3-(dimethylamino)propionyl]-forskolin; Colforsin dapropate hydrochloride
Application: A potent activator of adenylyl cyclase
CAS Number: 138605-00-2
Purity: >98%
Molecular Weight: 546.09
Molecular Formula: C27H43NO8•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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NKH 477 is a water-soluble analog of forskolin (sc-3562); potent activator of A cyclase (adenylyl cyclase); with some selectivity for cardiac A cyclase V (type V adenylyl cyclase). Stimulates bronchodilation (EC50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive .


References

1. Hosono, M., et al. 1992. J. Cardiovasc. Pharmacol. 19: 625-634.
2. Satake, K., et al. 1998. Br. J. Pharmacol. 123: 753-761.
3. Toya, Y., et al. 1998. J. Mol. Cell. Cardiol. 30: 97-108.

Physical State :
Solid
Solubility :
Soluble in water (40 mM), ethanol ( ~2.5 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and 1:1 solution of DMSO:PBS (pH 7.2) (~0.5 mg/ml).
Storage :
Desiccate at 4° C
Refractive Index :
n20D ~1.54 (Predicted)
IC50 :
Relaxation of histamine treated guinea pig smooth muscle : IC50 = 32 nM; Relaxes guinea pig tracheal smooth muscle precontracted with histamine: EC5050 = 32.6 nM; Stimulates bronchodilation: EC5050 = 32.6 nM; Potassium-induced contraction concetrations in smooth muscle strips: IC50 = 80 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AY5992600
PubChem CID :
444028
MDL Number :
MFCD00236421
EC Number :
266-410-9
SMILES :
CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)OC(=O)CCN(C)C.Cl

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Certificate of Analysis

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