Nitrofurazone (CAS 59-87-0)

Nitrofurazone, a nitrofuran derivative, has garnered significant attention in scientific research due to its broad-spectrum antimicrobial properties and diverse applications. Its mechanism of action primarily involves the disruption of bacterial cell metabolism and DNA synthesis. Nitrofurazone is converted into reactive intermediates within bacterial cells, which subsequently interact with cellular macromolecules, including proteins and nucleic acids. This interaction leads to the inhibition of key enzymes involved in bacterial metabolism and DNA replication, ultimately resulting in bacterial cell death. Research has explored the efficacy of nitrofurazone against various bacterial pathogens, including both Gram-positive and Gram-negative bacteria, as well as some protozoa. Furthermore, studies have investigated its potential for use in agricultural settings as a veterinary disinfectant and as an antimicrobial agent in aquaculture. Additionally, nitrofurazone has been examined for its wound-healing properties, with research focusing on its ability to promote tissue regeneration and reduce bacterial colonization in injured tissues. Overall, the versatile antimicrobial activity of nitrofurazone continues to drive ongoing research efforts aimed at exploring its potential applications across diverse fields.