Nisoxetine hydrochlorideA selective and potent inhibitor of norepinephrine transporter

Nisoxetine hydrochloride (CAS 57754-86-6)

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Synonym: (±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride; LY-94,939
Application: A selective and potent inhibitor of norepinephrine transporter
CAS Number: 57754-86-6
Molecular Weight: 307.82
Molecular Formula: C17H21NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nisoxetine hydrochloride is a selective and potent inhibitor of norepinephrine transporter with little or no affinity for a range of other neurotransmitter receptors. Nisoxetine hydrochloride is an inhibitor of SLC6A2.


References

1. Wong, D.T., et al. 1975. Life Sci. 17: 755-760.
2. Cheetham, S.C., et al. 1996. Neuropharmacology. 35: 63-70.
3. Zhu, M.Y., et al. 1997. J. Neurochem. 68: 134-141.
4. Shearman, L.P. and Meyer, L.S. 1998. J. Pharmacol. Exp. her. 284: 736-743.

Physical State :
Solid
Solubility :
Soluble in water (20 mg/ml), ethanol (50 mg/ml), and phosphate buffered saline (100 mM).
Storage :
Store at room temperature
Boiling Point :
404.8° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
SLC6A2: IC50 = 0.46 nM; ST: IC50 = 158 nM; DAT: IC50 = 505 nM; Plasmodium falciparum: IC50 = 0.79 µM
Ki Data :
ST: Ki= 1.4 nM (human); SLC6A2: Ki= 1.6 nM (human); SLC6A2: Ki= 5.1 nM; DAT: Ki= 30 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DA8325904
PubChem CID :
134453
MDL Number :
MFCD00153850
SMILES :
CNCCC(C1=CC=CC=C1)OC2=CC=CC=C2OC.Cl

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Certificate of Analysis

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Nisoxetine hydrochloride  Product Citations

See how others have used Nisoxetine hydrochloride. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24471494  Naganuma, F. et al. 2014. J. Neurochem. 129: 591-601.

Citations 1 to 1 of 1 total
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