Nilvadipine CAS: 75530-68-6
MF: C19H19N3O6
MW: 385.37
A potent calcium channel protein inhibitor and blocker.

Nilvadipine (CAS 75530-68-6)

Nilvadipine | CAS 75530-68-6 is rated 5.0 out of 5 by 1.
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Alternate Names: 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-(1-Methylethyl) Ester
Application: Nilvadipine is a potent calcium channel protein inhibitor and blocker
CAS Number: 75530-68-6
Purity: ≥98%
Molecular Weight: 385.37
Molecular Formula: C19H19N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nilvadipine is a potent calcium channel protein inhibitor and blocker (IC50 = 0.03 nM).


References

Gross, G.J., et al.: Gen. Pharmacol., 14, 677 (1983), Molyvdas, P.A. and Sperelakis, N.: J. Cardiovasc. Pharmacol., 8, 449 (1986), Mizuno, K., et al.: Res. Comm. Chem. Pathol. Pharmacol., 52, 3 (1986)

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in Ethanol
Storage :
Store at -20° C
Melting Point :
148-153° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CC1=C(C(C(=C(N1)C#N)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C

Download SDS (MSDS)

Certificate of Analysis

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Nilvadipine (CAS 75530-68-6)  Product Citations

See how others have used Nilvadipine (CAS 75530-68-6). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27716982  Heo, S. et al. 2016. Biomed. Chromatogr.

Citations 1 to 1 of 1 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-215567, is provided as a yellow crystalline powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-02-09
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Rated 5 out of 5 by from Paris et al Paris et al. (PubMed ID 25331948) found that nilvadipine inhibited A production and improved the clearance of A across the blood-brain barrier via spleen tyrosine kinase (Syk) inhibition located on Alzheimer's disease relevant epitopes on transgenic mice. -SCBT Publication Review -SCBT Publication Review
Date published: 2015-01-05
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