NilutamideAn androgen receptor inhibitor

Nilutamide (CAS 63612-50-0)

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Application: An androgen receptor inhibitor
CAS Number: 63612-50-0
Molecular Weight: 317.22
Molecular Formula: C12H10F3N3O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nilutamide is a non-steroidal and silent androgen receptor inhibitor. Nilutamide binds to androgen receptors and also inhibits androgen biosynthesis in vitro.


References

1. Raynaud, J.P., et al. 1979. J. Steroid. Biochem. 11: 93-99.
2. Raynaud, J.P., et al. 1984. Prostate. 5: 299-211.
3. Raynaud, J.P., et al. 1985. Prog. Clin. Biol. Res. 185A: 99-120.
4. Ayub, M. and Levell, M.J. 1987. J. Steroid Biochem. 28: 43-47.

Physical State :
Solid
Solubility :
Soluble in chloroform, ethanol (25 mM), methanol, and DMSO (25 mM). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
149° C
Boiling Point :
477.31° C (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
IC50 :
AR: IC50 = 9 nM (human)
pK Values :
pKa: 7.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NI9453300
PubChem CID :
4493
Merck Index :
14: 6544
MDL Number :
MFCD00864670
Beilstein Registry :
841906
SMILES :
CC1(C(=O)N(C(=O)N1)C2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)C

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Certificate of Analysis

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