Niguldipine hydrochlorideCAS: 113317-61-6
MF: C36H39N3O6•HCl
MW: 646.18
A selective α 1-adrenoceptor antagonist and dihydropyridine calcium channel blocker.

Niguldipine hydrochloride (CAS 113317-61-6)

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Synonym: 1,4-Dihydro-2,6-dimethyl-4-(3-n-itrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride
Application: A selective α 1-adrenoceptor antagonist and dihydropyridine calcium channel blocker
CAS Number: 113317-61-6
Molecular Weight: 646.18
Molecular Formula: C36H39N3O6•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Niguldipine HCl has been reported to be a highly selective α 1-adrenoceptor antagonist and dihydropyridine calcium channel blocker. More specifically, Niguldipine HCl has been shown to irreversibly inhibit T-type calcium channel currents in certain types of central and peripheral neurons and in smooth muscle cells. This compound has also been noted to inhibit noradrenaline-stimulated inositol phosphate accumulation. Additional reports demonstrate that Niguldipine HCl can potently and specifically inhibit bTREK-1 (IC50 = 5.07μM). Niguldipine HCl is an inhibitor of Mdr-1.


References

1. Robinson, J.P., et al. 1990. Br. J. Pharmacol. 100: 3-4. PMID: 2164859
2. Höllt, V., et al. 1992. Biochem. Pharmacol. 43: 2601-2608. PMID: 1352973
3. Stengel, W., et al. 1998. Eur. J. Pharmacol. 342: 339-345. PMID: 9548406
4. Liu, H., et al. 2007. J. Pharmacol. Exp. Ther. 323: 39-48. PMID: 17622574

Physical State :
Solid
Solubility :
Soluble in DMSO or methanol
Storage :
Store at room temperature
IC50 :
L-type Ca2+ channel: IC50 = 75 nM; T-type Ca2+ channels: IC50 = 244 nM; bTREK-1 : IC50 = 5.07 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6918096
SMILES :
CC1=C(C(C(=C(N1)C)C(=O)OCCCN2CCC(CC2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl

Download SDS (MSDS)

Certificate of Analysis

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