Nigericin sodium saltA polyether antibioitc K+ and Na+ ionophore

Nigericin sodium salt (CAS 28643-80-3)

Nigericin sodium salt | CAS 28643-80-3 is rated 5.0 out of 5 by 1.
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Synonym: Antibiotic K 178
Application: A polyether antibioitc K+ and Na+ ionophore
CAS Number: 28643-80-3
Purity: 98%
Molecular Weight: 746.94
Molecular Formula: C40H67O11•Na
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nigericin sodium salt, a polyether antibiotic K+ and Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential and stimulates ATPase activity leading to rapid intracellular acidification resulting in apoptosis. Nigericin•Na has shown a role for inducing caspase-1-independent necrotic cell death. Nigericin•Na has also been found to increase membrane potential accelerating the rate of superoxide generation approaching the rate obtained by antimycin. Nigericin•Na is an activator of Cryopyrin.


References

1. Vercesi, A.E., et al. 1993. J. Biol. Chem. 268: 8564-8568. PMID: 8473301
2. Furlong, I.J., et al. 1997. J. Cell Sci. 110: 653-661. PMID: 9092947
3. Sze, H. 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 5904-5908. PMID: 16592894
4. Hentze, H., et al. 2003. Cell Death Differ. 10: 956-968. PMID: 12934070
5. Rottenberg, H., et al. 2009. J. Biol. Chem. 284: 19203-19210. PMID: 19478336
6. Sze, H. 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 5904-5908. PMID: 16592894

Physical State :
Solid
Derived From :
Streptomyes hygroscopicus
Solubility :
Soluble in DMSO (10 mg/ml), ethanol (5 mg/ml), dichloromethane (10 mg/ml), and methanol (10 mg/ml).
Storage :
Store at -20° C
Refractive Index :
n20D 1.54
IC50 :
Plasmodium yoelii yoelii: IC50 = <0.001 nM; H9: IC50 = 140 nM (human); immunodeficiency virus 1: EC5050 = 6 nM (human)
pK Values :
pKa: 4.39
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QT6825000
PubChem CID :
16760591
Merck Index :
14: 6541
MDL Number :
MFCD00036825
Beilstein Registry :
3892398
SMILES :
C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)[O-])C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC.[Na+]

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Certificate of Analysis

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Nigericin sodium salt  Product Citations

See how others have used Nigericin sodium salt. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28938395  Pal, PB. et al. 2017. Endocrinology. 158: 3661-3675.

PMID: # 19478336  Rottenberg, H. et al. 2009. J. Biol. Chem.

PMID: # 17606922  Kikawada, T. et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 11585-11590.

Citations 1 to 3 of 3 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. This product is soluble in DMSO (10 mg/ml), ethanol (5 mg/ml), dichloromethane (10 mg/ml), and methanol (10 mg/ml). Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-20

Hi, in technical information says that solubility in DMSO is 50 mg/ml but in the answer provided to another user it says 10 mg/ml. Could you clarify which one is it? Thanks!

Asked by: Leya
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Rated 5 out of 5 by from Rottenberg et al Rottenberg et al. (PubMed ID 19478336) used Nigericin sodium salt to increase mitochondrial membrane potential and accelerate the rate of superoxide generation by catalyzing the exchange of potassium and hydrogen ions. -SCBT Publication Review
Date published: 2015-01-12
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