Niflumic acidA selective Cox-2 inhibitor and GPR35 activator

Niflumic acid (CAS 4394-00-7)

Niflumic acid | CAS 4394-00-7 is rated 5.0 out of 5 by 1.
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Synonym: Landruma
Application: A selective Cox-2 inhibitor and GPR35 activator
CAS Number: 4394-00-7
Purity: >99%
Molecular Weight: 282.22
Molecular Formula: C13H9F3N2O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Niflumic acid is a selective inhibitor of Cox-2 (cyclooxygenase-2). Niflumic acid acts as a potent anion channel blocker and GPR35 activator.


References

1. Barnett, J., et al. 1994. Biochim. Biophys. Acta. 1209: 130-139. PMID: 7947975
2. Johnson, J.L., et al. 1995. Arch. Biochem. Biophys. 324: 26-34. PMID: 7503555
3. White, M.M., et al. 1990. Mol. Pharm. 37: 720-724. PMID: 1692608

Usage :
Stable for at least 1 year when stored at room temperature. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. We do not recommend storing the aqueous solution for more than one day.
Physical State :
Solid
Solubility :
Soluble in ethanol (~50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (~50 mg/ml), DMSO (56 mg/ml at 25° C), and acetonitrile (~50 mg/ml).
Storage :
Store at room temperature
Melting Point :
203-204° C
Boiling Point :
~378.0° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Cox-2: IC50 = 918 nM (human); Cox-1: IC50 = 1.06 µM (human); GPR35: IC50 = 1.28 µM (human); mycophenolic acid (1 mM) glucuronidation by human UGT enzymes from liver microsomes: IC50 = 8 µM; mycophenolic acid (0.5 mM) glucuronidation by human kidney microsomes: IC50 = 8 µM
Ki Data :
Cox-2: Ki= 0.02 µM (sheep); Cox-1: Ki= 2 µM (sheep)
pK Values :
pKa: 1.7 (Predicted), pKb: 4.71 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
QT2999100
PubChem CID :
4488
Merck Index :
14: 6531
MDL Number :
MFCD00010569
EC Number :
224-516-2
SMILES :
C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F

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Certificate of Analysis

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Niflumic acid  Product Citations

See how others have used Niflumic acid. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 29899383  Livezey, M. et al. 2018. Cell Death Differ. 25: 1796-1807.

PMID: # 27125215  Wu, M. et al. 2016. Pflugers Arch.

Citations 1 to 2 of 2 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This chemical is supplied as a pale yellow powder. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2017-01-23
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Rated 5 out of 5 by from Strege Strege, et al. (PubMed ID 26359375) found that niflumic acid, a CACC inhibitor, inhibited the calcium current with greater efficiency and exhibited a higher potency against Ano1(+0)when compared to Ano1(-0). -SCBT Publication Review
Date published: 2015-03-12
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