(-)-Nicotine ditartrateA potent agonist of AChR

(-)-Nicotine ditartrate (CAS 65-31-6)

(-)-Nicotine ditartrate | CAS 65-31-6 is rated 5.0 out of 5 by 1.
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Synonym: (S)-3-(1-Methyl-2-pyrrolindinyl)pyridine, Di-d-tartrate
Application: A potent agonist of AChR
CAS Number: 65-31-6
Purity: >99%
Molecular Weight: 462.41
Molecular Formula: C10H14N22C4H6O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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(-)-Nicotine ditartrate is a potent agonist of AChR (nicotinic acetylcholine receptor). It stimulates autonomic ganglia and skeletal muscle neuromuscular junctions.


References

Rand, M.J. 1989. Prog. Brain Res. 79, 3. R: 23/24/25; S: 22-36/37/39-45

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), DMSO (75 nM), and ethanol.
Storage :
Store at room temperature
Boiling Point :
244.4° C at 760 mmHg
Optical Activity :
α20/D 20.82°
Ki Data :
α4β2: Ki= 1 nM; α1β1δγ: Ki= >1000 nM; α7: Ki= 4000 nM (rat); α7: Ki= 7130 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
QT0350000
PubChem CID :
10434468
Merck Index :
14: 6524
MDL Number :
MFCD00069368
EC Number :
200-607-2
SMILES :
CN1CCCC1C2=CN=CC=C2.C(C(C(=O)O)O)(C(=O)O)O.C(C(C(=O)O)O)(C(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Szyma ska Szyma ska, I. et al. (PubMed 17000100) used electrochemical impedance spectroscopy to study amyloid beta-peptide interactions with the potent AChR agonist (-)-Nicotine ditartrate and (-)-cotinine. -SCBT Publication Review
Date published: 2015-02-23
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