Nicotinamide 1,N6-ethenoadenine dinucleotideA β-NAD analog.

Nicotinamide 1,N6-ethenoadenine dinucleotide (CAS 38806-38-1)

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Synonym: β-Nicotinamide-1,N6-ethenoadenine dinucleotide
Application: A β-NAD analog.
CAS Number: 38806-38-1
Purity: ≥95%
Molecular Weight: 687.45
Molecular Formula: C23H27N7O14P2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nicotinamide 1,N6-ethenoadenine is an analog of β-NAD which can act as a fluorescent tag in nucleotide binary and ternary complex formation tests. The ADP-ribose moiety from NAD Free Acid (sc-208084) and its analogs can be transferred to proteins and protein-bound ADP-ribose by PARP-1 (ADP Poly(ADP-ribosyl) transferase, pADPRT). These studies show that NAD+ is a better substrate in polymer synthesis reactions than Nicotinamide 1,N6-ethenoadenine. In addition, polyacrylamide gels show that proteins bound with ADP-ribose from Nicotinamide 1,N6-ethenoadenine show slower motility through the gel. This study suggests that Nicotinamide 1,N6-ethenoadenine is useful for studying enzymes degrading poly(ADP-ribose) as a result of this compounds fluorescent nature.


References

1. Giovane, A., et al. 1985. FEBS Lett. 191: 191-194. PMID: 2996930
2. Oei, S.L., et al. 1996. FEBS Lett. 397: 17-21. PMID: 8941705
3. Basso, L.A., et al. 1997. Biochim. Biophys. Acta. 1340: 63-71. PMID: 9217015

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (250 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
170119
MDL Number :
MFCD00063546
SMILES :
C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C4N=CN6C5=NC=C6)O)O)O)O)C(=O)N

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Certificate of Analysis

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