Niban Antibody (F-10) is a mouse monoclonal IgG1 (kappa light chain) provided at 200 µg/ml
raised against amino acids 1-240 mapping at the N-terminus of Niban of human origin
Niban Antibody (F-10) is recommended for detection of Niban of human origin by WB, IP, IF and ELISA
Niban Antibody (F-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Niban (F-10): sc-374636.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Meaning "second" in Japanese, Niban, also known as FAM129A and Cell growth-inhibiting gene 39 protein, is a 928 amino acid cytoplasmic protein that regulates phosphoryation of many proteins that are involved in translation regulation, such as eIF2α, 4E-BP1 and p70 S6 kinase α. Since it ultimately functions as as activator of proteins, Niban has been implicated as a tumor marker for renal carcinoma, thyroid cancer and head and neck squamous cell carcinoma. Endoplasmic reticular stress induced in Niban knockout mice leads to upregulation of eIF2α and decreased phosphorylation of p70 S6 kinase α and 4E-BP1. Niban suppression eventually leads to apoptosis, therefore illustrating its involvement in the modulation of cell death signaling by regulating translation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
For Western Blot, is it recommended to use denatured or non-denatured conditions with Niban (F-10): sc-374636 monoclonal antibody?
Asked by: jenni
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
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