NialamideA nonselective MAO inhibitor

Nialamide (CAS 51-12-7)

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Synonym: N-Benzyl-β-(isonicotinylhydrazino)propionamide
Application: A nonselective MAO inhibitor
CAS Number: 51-12-7
Purity: ≥95%
Molecular Weight: 298.34
Molecular Formula: C16H18N4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nialamide is a pyridine-based small molecule non-selective inhibitor of MAO (monoamine oxidase) enzymes. As a non-selective inhibitor, Nialamide is described to inhibit both MAO A and B. Nialamide has been utilized to mediate quinolinic acid-induced hippocampal damage in studies.


References

1. Stone, T.W., et al. 2000. Amino Acids. 19: 275-281. PMID: 11026499
2. Wayment, H.K., et al. 2001. J. Neurosci. 21: 35-44. PMID: 11150317

Physical State :
Solid
Solubility :
Soluble in methanol (10 mg/ml), water (1:400), chloroform (1:150), alcohol (1:40), and acidic solutions (freely).
Storage :
Store at 4° C
Melting Point :
152-154° C (lit.)
Boiling Point :
~538.1° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D ~1.59 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 12.59 µM
pK Values :
pKa: 11.13 (Predicted), pKb: 3.6 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NS1225000
PubChem CID :
4472
Merck Index :
14: 6491
MDL Number :
MFCD00010106
EC Number :
200-079-3
Beilstein Registry :
492941
SMILES :
C1=CC=C(C=C1)CNC(=O)CCNNC(=O)C2=CC=NC=C2

Download SDS (MSDS)

Certificate of Analysis

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