NH125 CAS: 278603-08-0
MF: C27H45N2•I
MW: 524.56
An inhibitor of multiple kinases.

NH125 (CAS 278603-08-0)

NH125 | CAS 278603-08-0 is rated 5.0 out of 5 by 1.
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Alternate Names: eEF-2 Kinase Inhibitor; 1-Benzyl-3-cetyl-2-methylimidazolium iodide
Application: NH125 is an inhibitor of multiple kinases
CAS Number: 278603-08-0
Purity: ≥95%
Molecular Weight: 524.56
Molecular Formula: C27H45N2•I
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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NH125 is a cell-permeable imidazolium compound that has been used to study anticancer therapies. eEF2K is an ubiquitous protein kinase that phosphorylates and inactivates eEF2, and thus can modulate the rate of polypeptide chain elongation during translation. NH125 has been shown to inhibit cancer cell growth through inhibition of eukaryotic elongation eEF2K (factor-2 kinase). NH125 induces eEF2 phosphorylation; inhibition of cancer cell growth is correlated with induction of p-eEF2. NH125 is an inhibitor of CaMK.


References

1. Yamamoto, K. et al. 2000. Biosci. Biotechnol. Biochem. 64(4): 919-923. PMID: 10830522
2. Arora, S. et al. 2003. Cancer Res. 63(20): 6894-6899. PMID: 14583488
3. Arora, S. et al. 2004. Mol. Pharmacol. 66(3): 460-467. PMID: 15322237
4. Chen, Z. et al. 2011. J. Biol. Chem. 286(51): 43951-43958. PMID: 22020937
5. Devkota, A.K. et al. 2012. Biochemistry. 51(10): 2100-2112. PMID: 22352903

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), ethanol (75 mM), DMF (~15 mg/ml), and 1:2 solution of DMF:PBS (pH 7.2) (~0.3 mg/ml).
Storage :
Store at 4° C
Melting Point :
88.2-94.9° C
IC50 :
eEF-2 kinase: IC50 = 60 nM; YycG: IC50 = 6.6 µM; protein kinase C: IC50 = 7.5 µM; protein kinase A: IC50 = 80 µM; calmodulin-dependent kinase II: IC50 = >100 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD07370143
SMILES :
CCCCCCCCCCCCCCCCN1C=C[N+](=C1C)CC2=CC=CC=C2.[I-]

Download SDS (MSDS)

Certificate of Analysis

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NH125 (CAS 278603-08-0)  Product Citations

See how others have used NH125 (CAS 278603-08-0). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27045615  Smith, KP. et al. 2016. Assay Drug Dev Technol. 14: 194-206.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Bender Bender, CL. et al. (PubMed 25842244) found that NH125, an inhibitor of multiple kinases, reduces the level CPEB3, an RNA binding protein, to promote synaptic GluA2 expression. -SCBT Publication Review
Date published: 2015-07-12
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