NGIC-IMF: C23H16N4O
MW: 364.4
A potent, cell-permeable, and selective PKC inhibitor.

NGIC-I

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Application: A potent, cell-permeable, and selective PKC inhibitor
Purity: ≥95%
Molecular Weight: 364.4
Molecular Formula: C23H16N4O
* Refer to Certificate of Analysis for lot specific data (including water content).
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NGIC-I is a cell permeable, selective indolocarbazole, which functions as an inhibitor of PKC (protein kinase C). Studies on human CMV (cytomegalovirus) show that UL97 kinases can be inhibited by NGIC-I. As a result of inhibition via NGIC-I on UL 97 kinases, formation of pp65-rich aberrant cytoplasmic tegument aggregate. Studies indicate that protein kinase C is involved in many signal cascades via their function to phosphorylate proteins. The ability to regulate this protein is very useful to control signal transduction cascades. NGIC-I is an inhibitor of cGKI.


References

1. Gershburg, E., et al. 2004. Antimicrob. Agents Chemother. 48: 1900-1903. PMID: 15105156
2. Goldberg, M.D., et al. 2011. J Virol. [Epub ahead of print] . PMID: 21248036

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at 4° C
IC50 :
protein kinase C: IC50 = 75 nM; protein kinase A: IC50 = > 10 µM; protein kinase G: IC50 = 320 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3714
SMILES :
C1C2=C3C4=CC=CC=C4N(C3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5)CCC#N

Download SDS (MSDS)

Certificate of Analysis

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