NG-Amino-L-arginine hydrochlorideA potent inhibitor of NOS1, NOS2, and NOS3

NG-Amino-L-arginine hydrochloride (CAS 1031799-40-2)

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Synonym: L-NAA • HCl
Application: A potent inhibitor of NOS1, NOS2, and NOS3
CAS Number: 1031799-40-2
Molecular Weight: 225.7
Molecular Formula: C6H15N5O2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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NG-Amino-L-arginine hydrochloride is a potent inhibitor of NOS1, NOS2, and NOS3.


References

NG-amino-L-arginine: a new potent antagonist of L-arginine-mediated endothelium-dependent relaxation: J.M. Fukuto, et al.; BBRC 168, 458 (1990) Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG- methylarginine: S.S. Gross, et al.; BBRC 170, 96 (1990) Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle: L.J. Ignarro, et al.; BBRC 170, 843 (1990) Nitric oxide synthesis in the CNS endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues: L. Lambert, et al.; Life Sci. 48, 69 (1991) Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release: H.M. Vargas, et al.; J. Pharmacol. Exp. Ther. 257, 1208 (1991) Inhibition of purified nitric oxide synthase from rat cerebellum and macrophage by L-arginine analogs: Y. Komori, et al.; Arch. Biochem. Biophys. 315, 213 (1994) Inactivation of nitric oxide synthase isoforms by diaminoguanidine and NG-amino-L-arginine: D.J. Wolff & A. Lubeskie; Arch. Biochem. Biophys. 325, 227 (1996) Studies of neuronal nitric oxide synthase inactivation by diverse suicide inhibitors: R. Bryk, et al.; Arch. Biochem. Biophys. 369, 243 (1999) Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by N(G)-amino-L-arginine in vitro and in vivo: J.L. Vuletich, et al.; Mol. Pharmacol. 62, 110 (2002) ; Full Text Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group: A.J. Lee, et al.; Chem. Res. Toxicol. 18, 1927 (2005)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
SMILES :
Cl.Cl.NNC(=N)NCCC[C@H](N)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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