NFkappaB Activation Inhibitor IIIA TNF-α-stimulated NF kappa B activation inhibitor

NFκB Activation Inhibitor III (CAS 380623-76-7)

NFκB Activation Inhibitor III | CAS 380623-76-7 is rated 5.0 out of 5 by 1.
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Synonym: 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide; SM 7368; SM-7368
Application: A TNF-α-stimulated NF kappa B activation inhibitor
CAS Number: 380623-76-7
Molecular Weight: 328.68
Molecular Formula: C10H5ClN4O5S
* Refer to Certificate of Analysis for lot specific data (including water content).
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NF-κB Activation Inhibitor III is a thiazoloamide compound experimentally shown to inhibit TNF-α-stimulated NF-κB activation and MMP-9 in HT1080 upregulation. This upregulation corresponds to a concomitant inhibition of TNF-α-dependent cellular invasion. This compound has not been shown to affect the TNF-α-induced AP-1, occurring downstream of p38 activation.


References

1. Lee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336: 716-722. PMID: 16140265

Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11537217
SMILES :
C1=CC(=C(C=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-])Cl)[N+](=O)[O-]

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NFkappaB Activation Inhibitor III  Product Citations

See how others have used NFkappaB Activation Inhibitor III. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 23592398  Sun, L. et al. 2013. Stem cells (Dayton, Ohio). 31: 1454-66.

PMID: # 16140265  Lee, HY. et al. 2005. Biochem. Biophys. Res. Commun. 336: 716-722.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Samuel Samuel, T. et al. (PubMed 25134433) found that in SW480 cells, NF- B reporter activity, but not cytokine secretion, was inhibited by SM-7368, an NF- B inhibitor. -SCBT Publication Review
Date published: 2015-07-16
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