NFAT Activation Inhibitor III (INCA-6) is a potent and selective inhibitor of calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. A quinone based compound that is cellularly permeable and blocks NFAT dephosphorylation. In experiments, this product particularly showed ability to prevent transient outward K+ current reduction in 3-Hz paced left ventricular cardiomyocytes following tachycardia. NFAT Activation Inhibitor III does not exhibit effects on calcineurin activity or on calcineurin's downstream signaling.
1. Roehrl, M.H., et al. 2004. Biochemistry. 43: 16056-16066. PMID: 15610000 2. Roehrl, M.H., et al. 2004. Biochemistry. 43: 16067-16075. PMID: 15610001 3. Roehrl, M.H., et al. 2004. Proc. Natl. Acad. Sci. U.S.A. 101: 7554-7559. PMID: 15131267
Soluble in ethanol (5 mg/ml), and DMSO (20 mM).
Store at room temperature
182.66° C (Predicted)
464.20° C at 760 mmHg (Predicted)
1.38 g/cm3 (Predicted)
n20D 1.73 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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NFAT Activation Inhibitor III Product Citations
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FaralliFaralli, JA. et al. (PubMed 25450062) reported that suppression of NFATc1 activity via INCA-6, deregulated the expression of myocilin induced by dexamethasone. -SCBT Publication Review
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