NFAT Activation Inhibitor III (INCA-6) is a potent and selective inhibitor of calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. A quinone based compound that is cellularly permeable and blocks NFAT dephosphorylation. In experiments, this product particularly showed ability to prevent transient outward K+ current reduction in 3-Hz paced left ventricular cardiomyocytes following tachycardia. NFAT Activation Inhibitor III does not exhibit effects on calcineurin activity or on calcineurin's downstream signaling.
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See how others have used NFAT Activation Inhibitor III (CAS 3519-82-2). Click on the entry to view the PubMed entry .
PMID: # 23509367 Mikami, N. et al. 2013. J. Immunol. 190: 4046-55.
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