NFAT Activation Inhibitor III CAS: 3519-82-2
MF: C20H12O2
MW: 284.3
A potent and selective calcineurin-NFAT signaling inhibitor.

NFAT Activation Inhibitor III (CAS 3519-82-2)

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Alternate Names: INCA-6
Application: NFAT Activation Inhibitor III is a potent and selective calcineurin-NFAT signaling inhibitor
CAS Number: 3519-82-2
Purity: >95%
Molecular Weight: 284.3
Molecular Formula: C20H12O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

NFAT Activation Inhibitor III (INCA-6) is a potent and selective inhibitor of calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. A quinone based compound that is cellularly permeable and blocks NFAT dephosphorylation. In experiments, this product particularly showed ability to prevent transient outward K+ current reduction in 3-Hz paced left ventricular cardiomyocytes following tachycardia. NFAT Activation Inhibitor III does not exhibit effects on calcineurin activity or on calcineurin's downstream signaling.


References

1. Roehrl, M.H., et al. 2004. Biochemistry. 43: 16056-16066. PMID: 15610000
2. Roehrl, M.H., et al. 2004. Biochemistry. 43: 16067-16075. PMID: 15610001
3. Roehrl, M.H., et al. 2004. Proc. Natl. Acad. Sci. U.S.A. 101: 7554-7559. PMID: 15131267

Physical State :
Solid
Solubility :
Soluble in ethanol (5 mg/ml), and DMSO (20 mM).
Storage :
Store at room temperature
Melting Point :
182.66° C (Predicted)
Boiling Point :
464.20° C at 760 mmHg (Predicted)
Density :
1.38 g/cm3 (Predicted)
Refractive Index :
n20D 1.73 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
230748
SMILES :
C1=CC=C2C3C4=CC=CC=C4C(C2=C1)C5=C3C(=O)C=CC5=O

Download SDS (MSDS)

Certificate of Analysis

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NFAT Activation Inhibitor III (CAS 3519-82-2)  Product Citations

See how others have used NFAT Activation Inhibitor III (CAS 3519-82-2). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23509367  Mikami, N. et al. 2013. J. Immunol. 190: 4046-55.

Citations 1 to 1 of 1 total
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