NF 340 CAS: 202982-98-7
MF: C37H26N4O15S4•4Na
MW: 986.84
A P2Y antagonist demonstrating 520-fold selectivity for P2Y over P2Y, P2Y2, P2Y4, P2Y6 and P2Y12 receptors.

NF 340 (CAS 202982-98-7)

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Alternate Names: 4,4'-(Carbonylbis(imino-3,1-(4-methyl-phenylene)carbonylimino))bis(naphthalene-2,6-disulfonic acid) tetrasodium salt
Application: NF 340 is a P2Y antagonist demonstrating 520-fold selectivity for P2Y over P2Y, P2Y2, P2Y4, P2Y6 and P2Y12 receptors
CAS Number: 202982-98-7
Purity: ≥95%
Molecular Weight: 986.84
Molecular Formula: C37H26N4O15S44Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).
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NF 340 is a P2Y antagonist demonstrating 520-fold selectivity for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6 and P2Y12 receptors. This compound has also been shown to display competitive antagonism against ATPγS with pIC50 values of 6.43 and 7.14 in Ca2+ and cAMP assays, respectively.


References

1. Meis, S. et al. 2010. J. Pharmacol. Exp. Ther. 332(1): 238-247. PMID: 19815812
2. Bintig, W. et al. 2012. Purinergic Signal. 8(1): 71-80. PMID: 21956217

Physical State :
Solid
Solubility :
Soluble in water (20 mM), and DMSO (10 mM).
Storage :
Store at -20° C
Refractive Index :
n20D ~1.77 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
PubChem CID :
MDL Number :
MFCD18086895
SMILES :
CC1=C(C=C(C=C1)C(=O)NC2=C3C=C(C=CC3=CC(=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)NC4=C(C=CC(=C4)C(=O)NC5=C6C=C(C=CC6=CC(=C5)S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+]

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Certificate of Analysis

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NF 340 (CAS 202982-98-7)  Product Citations

See how others have used NF 340 (CAS 202982-98-7). Click on the entry to view the PubMed entry .

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PMID: # 33463722  Gruenbacher, G.|Gander, H.|Dobler, G.|Rahm, A.|Klaver, D.|Thurnher, M.| et al. 2021. Br J Pharmacol. 178: 1541-1555.

PMID: # 30821687  Prada, MP.|Syed, AU.|Buonarati, OR.|Reddy, GR.|Nystoriak, MA.|Ghosh, D.|Simó, S.|Sato, D.|Sasse, KC.|Ward, SM.|Santana, LF.|Xiang, YK.|Hell, JW.|Nieves-Cintrón, M.|Navedo, MF.| et al. 2019. Elife. 8:

PMID: # 31585052  FASEB J. 33: 13762-13774.

Citations 1 to 3 of 3 total
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