Neuronal Differentiation Inducer III (CAS 832115-62-5)
Neuronal Differentiation Inducer III is a cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 μM) in various stem/progenitor cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type channel-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
References
1. Schneider, Jay W., et al., 2008. Small-molecule activation of neuronal cell fate. Nature chemical biology. 4(7): 408-10. PMID: 18552832
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