Neuronal Differentiation Inducer IIIA neuronal differentiation inducing compound

Neuronal Differentiation Inducer III (CAS 832115-62-5)

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Synonym: N-cyclopropyl-5-thiophen-2-yl-1,2-oxazole-3-carboxamide
Application: A neuronal differentiation inducing compound
CAS Number: 832115-62-5
Purity: ≥97%
Molecular Weight: 234.27
Molecular Formula: C11H10N2O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Neuronal Differentiation Inducer III is a cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 μM) in various stem/progenitor cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type channel-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.


References

1. Schneider, Jay W., et al., 2008. Small-molecule activation of neuronal cell fate. Nature chemical biology. 4(7): 408-10. PMID: 18552832

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (50 mM).
Storage :
Store at 4° C
Melting Point :
175.40° C (Predicted)
Boiling Point :
468.09° C at 760 mmHg (Predicted)
Density :
1.40 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
pK Values :
pKa: 13.6 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
19582717
SMILES :
C1CC1NC(=O)C2=NOC(=C2)C3=CC=CS3

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Certificate of Analysis

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