Neurokinin AAn endogenous tachykinin agonist with preference for the NK-2R

Neurokinin A (CAS 86933-74-6)

Neurokinin A | CAS 86933-74-6 is rated 5.0 out of 5 by 1.
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Synonym: Substance K; Neuromedin L
Application: An endogenous tachykinin agonist with preference for the NK-2R
CAS Number: 86933-74-6
Molecular Weight: 1133.33
Molecular Formula: C50H80N14O14S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Neurokinin A is a member of the endogenous tachykinin agonist with preference for the NK-2R (NK-2 receptor) with greater potency as a bronchoconstrictor than Substance P (sc-201169). The comound has shown to be identical to substance K and neuromedin L1. Neurokinin A has been reported to effect reproduction by controlling at the hypothalamus level gonadotropin and prolactin secretion along with steroid secretion at the ovarian and gonadal level. An increase in inositol 1,4,5-trisphosphate (IP3) levels along with paralleled increase in intracellular free Ca2+ in BHK-21 cells with the NK-2R gene were stimulated with Neurokinin A. The compound has also been observed to induce contraction in muscle strips and single cells of the human sigmoid colon circular muscle. Neurokinin A has also been used to discover the location of tachykinin receptors.


References

1. Eistetter, H.R., et al. 1993. J. Cell. Biochem. 52: 84-91. PMID: 8391539
2. Debeljuk, L. and Lasaga, M. 1999. Peptides. 20: 285-299. PMID: 10422885
3. Cao, W., et al. 2000. Gastroenterology. 119: 51-61. PMID: 10889154

Physical State :
Solid
Solubility :
Soluble in water (1 g/l) at 20° C, 10% acetonitrile / water (1 mg/ml), and 5% Acetic Acid.
Storage :
Store at -20° C
Boiling Point :
~1610.7° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.58
Optical Activity :
α20/D -57.4°, c = 0.37 in 1 M AcOH
IC50 :
Neurokinin 2 receptor: IC50 = 1 nM (human); Neurokinin 1 receptor: IC50 = 3.5 nM (human); Neurokinin 3 receptor: IC50 = 45 nM (human)
Ki Data :
Neurokinin 2 receptor: Ki= 0.71 nM (human); Neurokinin 1 receptor: Ki= 630 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
55582
MDL Number :
MFCD00167560
SMILES :
CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N

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Certificate of Analysis

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Rated 5 out of 5 by from Cao et al Cao et al. (PubMed ID 10889154) found that neurokinin A activated Gq-linked NK(2) receptors, inducing contraction and increase in cytosolic Ca(2+) in human sigmoid circular smooth muscle. -SCBT Publication Review
Date published: 2015-04-09
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