Netilmicin Sulfate CAS: 56391-57-2
MF: (C21H41N5O7)2•5H2SO4
MW: 1441.5
An active aminoglycoside antibiotic.

Netilmicin Sulfate (CAS 56391-57-2)

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Alternate Names: 1-N-Ethylsisomicin
Application: Netilmicin Sulfate is an active aminoglycoside antibiotic
CAS Number: 56391-57-2
Molecular Weight: 1441.5
Molecular Formula: (C21H41N5O7)25H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Netilmicin Sulfate is an active aminoglycoside antibiotic against most Gram-negative and some Gram-positive bacteria, including certain strains resistant to gentamicin. Netilmicin is comparable to Gentamycin Sulfate (sc-203334), Amikacin (sc-278692) and Tobramycin (sc-204917) in bacteriological efficacy terms. The compound can be detected with the use of liquid chromatography. With an IC50 = 0.963 mM Netilmicin Sulfate inhibited rat erythrocyte PGD (6-phosphogluconate dehydrogenase) in vitro.


References

1. Campoli-Richards, D.M., et al. 1989. Drugs. 38: 703-756. PMID: 2689137
2. Adams, E., et al. 1998. J Chromatogr A. 812: 151-157. PMID: 9691316
3. Ciftçi, M., et al. 2002. Pol J Pharmacol. 54: 275-280. PMID: 12398160

Physical State :
Solid
Solubility :
Soluble in water (288 mg/ml at 25° C), DMSO (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C). Insoluble in alcohol (almost), and ether (almost).
Storage :
Store at 4° C
Melting Point :
194-198° C (dec.)
Boiling Point :
684.3° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
Optical Activity :
α20/D +78.3°, c = 0.7 in water; α26/D +164°, c = 3 in water
IC50 :
Phosphatidylserine-specific phospholipase A1: IC50 = 0.12 mM (rat); 6-phosphogluconate dehydrogenase: IC50 = 0.96 mM (rat erythrocyte)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
WK2286000
PubChem CID :
Merck Index :
14: 6479
MDL Number :
MFCD01311715
EC Number :
260-147-3

Download SDS (MSDS)

Certificate of Analysis

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