nestin Antibody (2C1.3A11) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
raised against a 150 amino acid epitope mapping near the C-terminus of human nestin
recommended for detection of nestin of mouse, rat and human origin by WB, IP, IF and IHC(P)
See nestin (10c2): sc-23927 for nestin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for nestin Antibody (2C1.3A11) for WB and IHC(P) applications. These reagents are now offered in bundles with nestin Antibody (2C1.3A11) (see ordering information below).
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Nestin is a major intermediate filament (IF) protein of embryonic central nervous system progenitor cells. It is also a component of the dynamic IF network during muscle development, where it polymerizes with Desmin and Vimentin. Nestin co-assembles with Vimentin or a-internexin and forms heterodimer coiled-coil molecules which then further assemble into 10 nml IFs. Deletion of the IF consensus rod domain in nestin alters nestin localization in CNS precursor cells and radial glial cells in vivo. Nestin is a marker for neuroepithelial stem cells, glioma cells and tumor endothelial cells during rapid growth. During axon elongation of differen-tiation neurons, nestin localizes to the growth cones and may play a role in growth cone guidance. In the rat adrenal gland, nestin is expressed by the zona fasciculata and the zona reticularis. Nestin is also expressed by dermatomal cells and by myoblasts during the earliest stages of myogenesis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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