Necrosis Inhibitor, IM-54 is a cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 μM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 μM H2O2). Does not offer protection against Etoposide induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 μM.
1. Dodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15: 3114-3118. PMID: 15878276
See how others have used Necrosis Inhibitor, IM-54. Click on the entry to view the PubMed entry .
PMID: # 27028595 Matsuoka, S. et al. 2016. PLoS ONE. 11: e0150496.
PMID: # 26629768 Hao, H. et al. 2016. Anticancer Drugs. 27: 192-203.
PMID: # 23353183 Kang, D. et al. 2013. Cell. Signal. 25: 1288-300.
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