Necrosis Inhibitor, IM-54

Necrosis Inhibitor, IM-54 (CAS 861891-50-1)

Necrosis Inhibitor, IM-54 | CAS 861891-50-1 is rated 5.0 out of 5 by 1.
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Synonym: 2-(1H-indol-3-yl)-3-pentylamino-maleimide
Application: A selective inhibitor of oxidative stress-induced necrotic cell death
CAS Number: 861891-50-1
Purity: ≥95%
Molecular Weight: 325.40
Molecular Formula: C19H23N3O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Necrosis Inhibitor, IM-54 is a cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 μM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 μM H2O2). Does not offer protection against Etoposide induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 μM.


References

1. Dodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15: 3114-3118. PMID: 15878276

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml), methanol (10 mg/ml), ethanol (~1 mg/ml), 1:2 solution of DMSO:PBS(pH 7.2) (~0.3 mg/ml), dichloromethane, and DMF (~20 mg/ml).
Storage :
Store at 4° C
Boiling Point :
511.49° C at 760 mmHg (Predicted)
Density :
1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
pK Values :
pKb: 1.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
16760577
MDL Number :
MFCD18382109
SMILES :
CCCCCNC1=C(C(=O)N(C1=O)C)C2=CN(C3=CC=CC=C32)C

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Certificate of Analysis

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Necrosis Inhibitor, IM-54  Product Citations

See how others have used Necrosis Inhibitor, IM-54. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 27028595  Matsuoka, S. et al. 2016. PLoS ONE. 11: e0150496.

PMID: # 26629768  Hao, H. et al. 2016. Anticancer Drugs. 27: 192-203.

PMID: # 23353183  Kang, D. et al. 2013. Cell. Signal. 25: 1288-300.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from De Araujo CB; et al De Araujo CB; et al. (PubMed ID: 24764300) utilized IM-54 to block cell death triggered by pep 5 in HeLa cells. -SCBT Publication Review
Date published: 2015-04-21
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