Nebivolol hydrochlorideCAS: 152520-56-4
MF: C22H25F2NO4•HCl
MW: 441.9
A highly selective β1-adrenoceptor antagonist.

Nebivolol hydrochloride (CAS 152520-56-4)

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Synonym: (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
Application: A highly selective β1-adrenoceptor antagonist
CAS Number: 152520-56-4
Purity: ≥98%
Molecular Weight: 441.9
Molecular Formula: C22H25F2NO4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nebivolol hydrochloride is the hydrochloride salt preparation of Nebivolol (sc-279910), a highly selective antagonist of the β1-AR (β1-adrenoceptor) (Ki = 0.88 nM, β2-adrenoceptor Ki = 48 nM). Nebivolol is described to produce vasodilation through inducing vascular production of NO, mediated through Nebivolol agonism of the β3-adrenoceptor. Nebivolol demonstrates some affinity at the α1-adrenergic (Ki = 1160 nM), SR-1A (serotonin 5-HT1A) (Ki = 20 nM) and 5-HT2 (Ki = 700 nM), dopamine D2 (Ki = 4000 nM), and histamine H1 (Ki = 2400 nM) receptors.


References

1. Pauwels, P.J., et al. 1988. Mol. Pharmacol. 34: 843-851. PMID: 2462161
2. de Groot, A.A., et al. 2003. J. Cardiovasc. Pharmacol. 42: 232-236. PMID: 12883327
3. Georgescu, A., et al. 2007. Eur. J. Pharmacol. 570: 149-158. PMID: 17612521
4. Georgescu, A., et al. 2008. Pharmacology. 81: 110-117. PMID: 17952013

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C), ethanol (10 mM), DMSO (88 mg/ml at 25° C), methanol, and DMF.
Storage :
Desiccate at room temperature
Melting Point :
219-222° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DJ2548910
PubChem CID :
11626384
Merck Index :
14: 6432
MDL Number :
MFCD07357273
SMILES :
C1CC2=C(C=CC(=C2)F)O[[email protected]]1[[email protected]](CNC[[email protected]@H]([[email protected]@H]3CCC4=C(O3)C=CC(=C4)F)O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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