Nebivolol hydrochlorideCAS: 152520-56-4
MF: C22H25F2NO4•HCl
MW: 441.9
A highly selective β1-adrenoceptor antagonist.

Nebivolol hydrochloride (CAS 152520-56-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 122ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: (±)-[2R*(1S*5S*(S*))]-α,α'-[Iminobis(methylene)bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)
Application: A highly selective β1-adrenoceptor antagonist
CAS Number: 152520-56-4
Purity: ≥98%
Molecular Weight: 441.9
Molecular Formula: C22H25F2NO4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Nebivolol hydrochloride is the hydrochloride salt preparation of Nebivolol (sc-279910), a highly selective antagonist of the β1-AR (β1-adrenoceptor) (Ki = 0.88 nM, β2-adrenoceptor Ki = 48 nM). Nebivolol is described to produce vasodilation through inducing vascular production of NO, mediated through Nebivolol agonism of the β3-adrenoceptor. Nebivolol demonstrates some affinity at the α1-adrenergic (Ki = 1160 nM), SR-1A (serotonin 5-HT1A) (Ki = 20 nM) and 5-HT2 (Ki = 700 nM), dopamine D2 (Ki = 4000 nM), and histamine H1 (Ki = 2400 nM) receptors.


1. Pauwels, P.J., et al. 1988. Mol. Pharmacol. 34: 843-851. PMID: 2462161
2. de Groot, A.A., et al. 2003. J. Cardiovasc. Pharmacol. 42: 232-236. PMID: 12883327
3. Georgescu, A., et al. 2007. Eur. J. Pharmacol. 570: 149-158. PMID: 17612521
4. Georgescu, A., et al. 2008. Pharmacology. 81: 110-117. PMID: 17952013

Appearance :
Physical State :
Solubility :
Soluble in water (<1 mg/ml at 25° C), ethanol (10 mM), DMSO (88 mg/ml at 25° C), methanol, and DMF.
Storage :
Desiccate at room temperature
Melting Point :
219-222° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 6432
MDL Number :
C1CC2=C(C=CC(=C2)F)O[[email protected]]1[[email protected]](CNC[[email protected]@H]([[email protected]@H]3CCC4=C(O3)C=CC(=C4)F)O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 111ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 18ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.