(ndash)-Nutlin-3An inhibitor of p-53-MDM2 interaction

(–)-Nutlin-3 (CAS 675576-98-4)

(andndash)-Nutlin-3, CAS 675576-98-4 is rated 4.0 out of 5 by 1.
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Synonym: Nutlin-3a; (-)-4-(4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
Application: An inhibitor of p-53-MDM2 interaction
CAS Number: 675576-98-4
Purity: ≥98%
Molecular Weight: 581.49
Molecular Formula: C30H30Cl2N4O4
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(−)-Nutlin-3 is a cis-imidazoline analog, which inhibits the interaction between the proteins p53 and MDM2. It is known that (−)-Nutlin-3 appears as the first peak during chiral purification of racemic Nutlin-3 (sc-45061). Studies indicate that (−)-Nutlin-3 amplifies the expression of p53 regulated genes and shows antiproliferative effects in cells containing functional p53. (−)-Nutlin-3 is a useful tool in studying the regulation of tumors in cells.


References

1. Lane, D.P. and Hupp, T.R. 2003. Drug Discov. Today. 8: 347-355. PMID: 12681938
2. Tovar, C., et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 1888-1893. PMID: 16443686
3. Shinohara, T., et al. 2007. Tanpakushitsu Kakusan Koso. 52: 1816-1817. PMID: 18051440

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11433190
MDL Number :
MFCD07784509
SMILES :
CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

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(ndash)-Nutlin-3  Product Citations

See how others have used (ndash)-Nutlin-3. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25444910  Dogra, S. et al. 2015. Cancer Lett. 356: 953-61.

PMID: # 11073822  Ouyang, H. et al. 2000. Am. J. Pathol. 157: 1623-31.

Citations 1 to 2 of 2 total
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Rated 4 out of 5 by from An increase in both MDM2 and cleaved MDM2 An increase in both MDM2 and cleaved MDM2 protein was observed by WB in Hep G2 cells post treatment with (-)-Nutlin-3. -SCBT QC
Date published: 2015-05-19
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