(−)-Nutlin-3 is a cis-imidazoline analog, which inhibits the interaction between the proteins p53 and MDM2. It is known that (−)-Nutlin-3 appears as the first peak during chiral purification of racemic Nutlin-3 (sc-45061). Studies indicate that (−)-Nutlin-3 amplifies the expression of p53 regulated genes and shows antiproliferative effects in cells containing functional p53. (−)-Nutlin-3 is a useful tool in studying the regulation of tumors in cells.
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See how others have used (ndash)-Nutlin-3. Click on the entry to view the PubMed entry .
PMID: # 25444910 Dogra, S. et al. 2015. Cancer Lett. 356: 953-61.
PMID: # 11073822 Ouyang, H. et al. 2000. Am. J. Pathol. 157: 1623-31.
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