NCI-H929 Whole Cell Lysate: sc-364786

NCI-H929 whole cell lysate is derived from the NCI-H929 cell line, which originates from a human multiple myeloma. This lysate is extensively used in research to study the molecular mechanisms of cancer biology, particularly multiple myeloma. NCI-H929 cells are characterized by their high production of immunoglobulin G (IgG) and are used as a model to investigate the signaling pathways involved in cell proliferation, survival, and apoptosis. Researchers utilize NCI-H929 whole cell lysate to analyze key signaling pathways such as the PI3K/Akt, NF-κB, and JAK/STAT pathways, which play crucial roles in the growth and survival of myeloma cells. This lysate facilitates the study of protein expression, post-translational modifications, and interactions between signaling molecules that regulate these pathways. Additionally, it is employed to examine the effects of various chemical modulators on these signaling pathways, providing insights into the molecular mechanisms of myeloma cell behavior and resistance to apoptosis. Recent studies have leveraged NCI-H929 whole cell lysate for proteomic and genomic analyses to identify novel proteins and signaling networks involved in multiple myeloma progression. By offering detailed insights into the molecular and cellular mechanisms underlying myeloma biology, NCI-H929 whole cell lysate remains a vital resource for advancing cancer research and understanding the complexities of myeloma signaling.