NBI-31772An insulin-like growth factor-I binding protein (IGFBP) ligand

NBI-31772 (CAS 374620-70-9)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 99ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: [1-(3′,4′-Dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic Acid]
Application: An insulin-like growth factor-I binding protein (IGFBP) ligand
CAS Number: 374620-70-9
Purity: ≥95%
Molecular Weight: 341.27
Molecular Formula: C17H11NO7
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

NBI-31772 is a non-peptide ligand. Exhibits high-affinity towards all six human insulin-like growth factor-I binding proteins (IGFBPs). NBI-31772 displaces insulin-like growth factor-I (IGF-I) from the IGF-I:IGFBP complex in 3T3 fibroblasts, but does not interact with the IGF receptors.


References

Chen, C., et al. 2001. J. Med. Chem. 44, 4001. Liu, X.J., et al. 2001. J. Biol. Chem. 276, 32419.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml).
Storage :
Store at -20° C
Melting Point :
283.14° C (Predicted)
Boiling Point :
394.84° C at 760 mmHg (Predicted)
Density :
1.77 g/cm3 (Predicted)
Refractive Index :
n20D 1.80 (Predicted)
Ki Data :
IGFBP2: Ki= 1.18 nM; IGFBP4: Ki= 1.54 nM; IGFBP6: Ki= 16.6 nM; IGFBP1: Ki= 3.36 nM; IGFBP5: Ki= 3.90 nM; IGFBP3: Ki= 5.64 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9927940
SMILES :
C1=CC(=O)C(=O)C=C1C(=O)C2=C3C=C(C(=CC3=CC(=C(O)O)N2)O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Does this inhibitor bind to IGFBP7?

Asked by: scientist101
Thank you for your question. NBI-31772 is a non-peptide ligand that exhibits high-affinity towards all six human insulin-like growth factor-I binding proteins (IGFBPs). NBI-31772 displaces insulin-like growth factor-I (IGF-I) from the IGF-I:IGFBP complex in 3T3 fibroblasts, but does not interact with the IGF receptors.
Answered by: Technical Support
Date published: 2019-05-31
  • y_2019, m_9, d_22, h_20CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_222047, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 100ms
  • QUESTIONS, PRODUCT
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 63ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.