NaringeninThe aglucon of naringin

Naringenin (CAS 480-41-1)

Naringenin | CAS 480-41-1 is rated 5.0 out of 5 by 1.
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Synonym: 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; (R,S)-Naringenin; (+/-)-5,7,4-Trihydroxyflavanone; 5,7,4-Trihydroxyflavanone
Application: The aglucon of naringin
CAS Number: 480-41-1
Purity: 98%
Molecular Weight: 272.25
Molecular Formula: C15H12O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Naringenin is a flavonoid commonly found in grapefruits which functions as an antioxidant, free radical scavenger, anti-inflammatory compound, carbohydrate metabolism promoter, and immune system modulator. Studies indicate that in vitro Naringenin reduces oxidative damage to DNA. In addition, Naringenin potently inhibits the secretion of very-low-density lipoproteins by cells. Furthermore, Naringenin has been shown to reduce cholesterol concentrations in hepatocytes and plasma cells via inhibiting HMGCR (HMG-CoA reductase). Studies conducted on Hepatitis C virus particles demonstrate that Naringenin can inhibit the virus via a PPAR-mediated mechanism by inhibiting the long term assembly of the virus.


References

1. Fuhr, U., et al. 1993. Br J Clin Pharmacol. 35: 431-436. PMID: 8485024
2. Nahmias, Y., et al. 2008. Hepatology. 47: 1437-1445. PMID: 18393287
3. Goldwasser, J., et al. 2011. J Hepatol. [Epub ahead of print]. PMID: 21354229

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ether, methanol, ethanol, and DMSO. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
247-250° C (lit.)
Boiling Point :
~577.5° C at 760 (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
Cytotoxicity : IC50 = 36.75 µM (Human HCT116 cells )
pK Values :
pKa: 7.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DJ2981530
PubChem CID :
439246
Merck Index :
14: 6424
MDL Number :
MFCD00006844
EC Number :
266-769-1
Beilstein Registry :
280888
SMILES :
C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=C(C=C3)O

Download SDS (MSDS)

Certificate of Analysis

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Naringenin  Product Citations

See how others have used Naringenin. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 30468746  Diosa-Toro, M.|Troost, B.|van de Pol, D.|Heberle, AM.|Urcuqui-Inchima, S.|Thedieck, K.|Smit, JM.| et al. 2019. Antiviral Res. 161: 90-99.

PMID: # 28603085  Fernández-Del-Río, L. et al. 2017. Free Radic. Biol. Med. 110: 176-187.

PMID: # 28386622  Zucoloto, AZ. et al. 2017. Inflamm. Res. 66: 591-602.

PMID: # 28157234  Frabasile, S. et al. 2017. Sci Rep. 7: 41864.

PMID: # 27045367  Manchope, MF. et al. 2016. PLoS ONE. 11: e0153015.

PMID: # 27260463  Pinho-Ribeiro, FA. et al. 2016. J. Nutr. Biochem. 33: 8-14.

Citations 1 to 6 of 6 total

i purchased the product almost 2 years back. i have been storing it at RT AS INSTRUCTED ON ITS BOTTLE. BUT NOW WHEN I SEE INSTRUCTIONS, IT MENTIONS STORAGE AT -20DEG. PLEASE TELL ABOUT THE EFFICACY IF I USE. NARINGENIN 480-41-1

Asked by: P SHARMA
Thank your for your question. Unfortunately we are not able to provide efficacy information for this situation for this biochemical as we have not tested storing it at room temperature. Since the biochemical was purchased 2 years ago, it is no longer covered by our warranty. I would suggest giving it a try, since it can be kept at ambient temperatures for shorter periods of time. Please reach out to your local distributor for further assistance.
Answered by: Tech Service
Date published: 2019-07-03

Hi, please let me know what is the difference brtween Naringenin cas 480-41-1 and 67604-48-2, which one is suitable to study in-vivo on rat?

Asked by: Afshin
Thank you for your question. We do not recommend nor support the use of this research chemical for in vivo applications. The two forms of Naringenin have different uses, you can read more about them on their product blocking here on our website: https://www.scbt.com/scbt/product/naringenin-480-41-1?requestFrom=search https://www.scbt.com/scbt/product/plus-minus-naringenin-67604-48-2?requestFrom=search
Answered by: Tech Service
Date published: 2019-05-30

Sir/Ma'am. Is it possible to buy only 1gram of naringenin in place of 25g?

Asked by: Anki
Thank you for your question. The smallest quantity that we can provide for this chemical, Naringenin: sc-219338, is 25 grams. We are unable to offer a smaller quantity for purchase at this time.
Answered by: Technical Support
Date published: 2016-10-20
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Rated 5 out of 5 by from Goldwasser et al Goldwasser et al. (PubMed ID 21354229) found that Naringenin inhibited the assembly of infectious hepatitis C via PPARalpha activation. -SCBT Publication Review
Date published: 2015-06-15
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